Figure 4
3D structure and rSS of a glycine riboswitch. (a) The RNA puzzle structure model (the first 24 and last 12 nucleotides are in blue; the middle 48 nucleotides are in orange) superimposed on the experimental structure (gray) as a whole chain. (b) The blue and orange parts of the structure model separately superimposed on the experimental structure with r.m.s.ds of 10.6 and 3.8 Å, respectively. (c) Schematic of rSS. Base pairs that are in the experimental 3D structure but not in the 3D structure model are shown by magenta dashed lines. The base pair that is in the structure model but not in the experimental 3D structure is shown by a red dotted line. Base pairs common to experimental and computational 3D structures are shown by black solid lines. (d) Sequence, rSS of the experimental structure (from DSSR) and rSS of the structure model, where assignments by DSSR and by CSSR are identical. The colors of the sequences correspond to the colors of the corresponding structure models in (a) and (b). Nucleotides with different base pairing in the experimental and computational 3D structures are shaded. |