Crystal structure of the putative cell-wall lipoglycan biosynthesis protein LmcA from Mycobacterium smegmatis

Patel, O.; Brammananth, R.; Dai, W.; Panjikar, S.; Coppel, R.L.; Lucet, I.S.; Crellin, P.K.

doi:10.1107/S2059798322001772

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 5
AlphaFold2-derived predictions of MSMEG_0317 (AF MSMEG_0317) and Rv0227c (AF Rv0227c). (a) Structure of AF Rv0227c. (b) Structure of AF MSMEG_0317Δ. (c) Overlay of the crystal structure of MSMEG_0317Δ with AF Rv0227c and a close-up view of the base of the β-barrel core. Loop 6 in AF Rv0227c is resolved and this loop contains two additional β-strands. Loop 9 in AF Rv0227c adopts an `out' or `open' conformation, in contrast to loop 9 in the MSMEG_0317Δ crystal structure, which adopts an `in' or `closed' conformation. (d) Overlay of the crystal structure of MSMEG_0317Δ with AF MSMEG_0317 and a close-up view of the base of the β-barrel core. Loop 6 in AF MSMEG_0317 is resolved in a similar position as in AF Rv0227c, including the additional two β-strands. Like AF Rv0227c, loop 9 in AF MSMEG_0317 adopts an `out' or `open' conformation. (e) Comparison of the enclosed cavities of the MSMEG_0317Δ, AF Rv0227c and AF MSMEG_0317 models. See also Supplementary Fig. S7.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 78| Part 4| April 2022| Pages 494-508

https://doi.org/10.1107/S2059798322001772

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