Figure 6
Open and closed conformations of SmeCOSe showing the rearrangement of Asn146–Asp500 (inter-subunit) to Asn498–Asp500 (intra-subunit). PDB entry 7ptj (chain A, blue tones; chain B, purple tones) shows the open conformation, whereas PDB entry 6g60 (chain A, yellow tones; chain B, dark yellow tones) shows the closed conformation. The Asn146–Asp500 (closed conformation) and Asn498–Asp500 (open conformation) interactions are highlighted in black. The direction of the movement of Leu499 is also highlighted. |