Figure 2
MDCC is bound in a composite hydrophobic binding pocket at the hexamer interface. (a) MDCC is sandwiched between loop Val368–Leu377 and the catalytic loop (Leu394–Gln405) in molecule C, as well as part of two Src loops (Phe349–Phe352 and Phe352–Asn354) from molecules A and B. MDCC is shown in stick representation and is enveloped by 2mFo − DFc electron-density maps. (b) MDCC binding pocket. Key residues lining the pocket are indicated. The coloring scheme for the protomers is the same as in Fig. 1(a). |