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Figure 3
Conformational changes of the Src loop induced by MDCC binding. (a) Structural superimposition of MDCC–Hsp90αMC (magenta), yeast Hsc82 (light blue; PDB entry 2cge) and the yeast Hsc82–Aha1 complex (Hsc82, green; Aha1, cyan; PDB entry 6xlb). (b) Structural superimposition of MDCC–Hsp90αMC (magenta) and closed-state full-length human Hsp90α (gray; PDB entry 7l7j). The insets detail the Src-loop conformations, with the two Phe residues shown in stick representation.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
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