Crystal structure of the middle and C-terminal domains of Hsp90α labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target

Peng, S.; Woodruff, J.; Pathak, P.K.; Matts, R.L.; Deng, J.

doi:10.1107/S2059798322002261

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 5
The hexamer interface involving the catalytic loop from one protomer (chain C, magenta) of a homodimer contacting the MC domain in a neighboring molecule (chain B, cyan). The catalytic loops are indicated and the three helices in the MC domain are highlighted in red. Each inset details the interactions between the catalytic loop and the MC domain.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 78| Part 5| May 2022| Pages 571-585

https://doi.org/10.1107/S2059798322002261

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