Crystal structure of the middle and C-terminal domains of Hsp90α labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target

Peng, S.; Woodruff, J.; Pathak, P.K.; Matts, R.L.; Deng, J.

doi:10.1107/S2059798322002261

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

IUCr IT WDC

home archive editors for authors for readers submit subscribe open access

view article

Figure 7
Hexamer interface involving Trp320 in the MD and Arg620 in the CTD loop. (a) Chain A (green) and chain D (yellow) are shown as cartoons, and chain B and chain C are shown as surfaces. The coloring scheme is the same as in Fig. 1

(a). Trp320 and Arg620 are shown as spheres. The insets (b, c) detail the molecular interactions involving Trp320 and Arg620. Hydrogen bonds are shown as red dashed lines.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 78| Part 5| May 2022| Pages 571-585

https://doi.org/10.1107/S2059798322002261

Open

access

Follow Acta Cryst. D

Search IUCr Journals		doi		Advanced search
Author		volume	page