Crystal structure of the middle and C-terminal domains of Hsp90α labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target

Peng, S.; Woodruff, J.; Pathak, P.K.; Matts, R.L.; Deng, J.

doi:10.1107/S2059798322002261

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 8
Structures of MDCC and the inhibitors. (a) MDCC. (b) Derrubone. (c) Coumermycin A1. (d) Chlorobiocin. (e) Triptolide. The red circles indicate the coumarin core.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 78| Part 5| May 2022| Pages 571-585

https://doi.org/10.1107/S2059798322002261

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