Crystal structure of the middle and C-terminal domains of Hsp90α labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target

Peng, S.; Woodruff, J.; Pathak, P.K.; Matts, R.L.; Deng, J.

doi:10.1107/S2059798322002261

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 9
(a) Fluorescence-based competition assay. Various coumarin core-containing inhibitors were pre-incubated with Hsp90αMC before adding MDCC, the fluorescence intensity of which was monitored over time. Models of derrubone (b) and chlorobiocin (c) bound in Hsp90αMC (chain A, green; chain B, cyan; chain C, magenta).

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 78| Part 5| May 2022| Pages 571-585

https://doi.org/10.1107/S2059798322002261

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