Figure 8
Views of the active site of SARS-CoV-2 Mpro in complex with ABT-957 (a) under cryogenic conditions (Redhead et al., 2021 ) and (b) at room temperature. Contours for the ligand density are drawn at 3σ. (c, d) Two slightly displaced views of the active site of SARS-CoV-2 Mpro in complex with ABT-957 to show the conformational differences observed, particularly for the oxopyrrolidine and benzyl moieties of ABT-957 when bound to Mpro, at cryo temperature (cyan) and room temperature (green). The structures were superimposed using PyMOL (Schrödinger) |