Figure 2
The monomer–monomer interface of Kv2.1 T1 is a conserved charged surface. (a) Surface representation of Kv2.1 T1 colored by electrostatic potential calculated using APBS. The gradient is from −5kT/e (red) to +5kT/e (blue). Top: as observed from the side view of the X-ray structure in Fig. 1(b). Bottom: subunits are rotated 90° with respect to the X-ray structure. (b) Surface representation of Kv2.1 T1 colored by sequence conservation (purple for most conserved and green for least conserved). Conservation scores were calculated using ConSurf. The top and bottom views are subunits rotated as described for (a). |