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![[Figure 5]](rs5003fig5mag.jpg)
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Figure 5
Comparison of EP and EP–TL00150 structures at 100 K. (a) EP structure with 10%(v/v) DMSO. (b) TL00150-soaked EP structure with 10%(v/v) DMSO. The r.m.s.d. (root-mean-square deviation) of EP with 10%(v/v) DMSO to TL00150-soaked EP with 10%(v/v) DMSO is 0.178 Å (residues 1–330). EP with 10%(v/v) DMSO and TL00150-soaked EP with 10%(v/v) DMSO are coloured green and grey, respectively. The flap domain, catalytic dyad (Asp35 and Asp219), Asp119, DMSO, water and TL00150 are depicted. The 2Fo − Fc electron-density maps contoured at 1σ are shown in blue for the flap domain, Asp35, Asp119 and Asp219, in cyan for DMSO molecules, in red for water and in orange for TL00150. |
![[Figure 5]](rs5003fig5.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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