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![[Figure 6]](dw5231fig6mag.jpg)
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Figure 6
Active-site structure comparison of the KEase family. Metal-binding residues are shown as red sticks in DAEase, cyan sticks in DTEase and black sticks in LREase. Residues making hydrogen bonds to D-fructose at its O1, O2 and O3 sites are shown in purple in DAEase, gray in DTEase and yellow in LREase. Residues making hydrogen bonds to D-fructose at its O4, O5 and O6 sites involve Ile66 and Ala107 in Agtu-DAE, Tyr6 in Clce-DAE, Cys66 in Psci-DTE, His12 and Ser69 in Mesp-LRE and remain unknown in other KEases due to the lack of a complex structure with the substrate. Hydrophobic residues in the active center are also shown as sticks in various colors. |
![[Figure 6]](dw5231fig6.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
