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![[Figure 5]](ni5021fig5mag.jpg)
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Figure 5
Structural features of the RBD Q498Y–ACE2 complex. (a) Comparison of the overall complex structures of ACE2 complexed with RBD wt (image prepared with the atomic coordinates deposited in the Protein Data Bank; accession code 6m0j) and RBD Q498Y, as indicated in the figure. To compare the overall docking similarity between the two complexes, the RBD Q498Y–ACE2 structure was superposed on the α carbons of ACE2 in complex with RBD wt (PDB entry 6m0j). The structural alignment and all figures were generated in PyMOL (version 2.5.2). The middle panel in (a) shows both complexes structurally aligned on ACE2. The RBD and ACE2 proteins are shown as cartoons in pale yellow and gray, respectively. For purposes of comparison, the RBD Q498Y–ACE2 complex is shown in blue in the middle panel. To ease visualization, position 498 is highlighted with dots and the zinc(II) ions are displayed as purple spheres. (b) 2Fo − Fc electron-density map (contour level 1.0σ) surrounding position 498 of RBD in the refined structure of the RBD Q498Y–ACE2 complex shown as a blue mesh. |
![[Figure 5]](ni5021fig5.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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