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Figure 7
Glycosylation with FA1[6] on Asn483 of both monomer chains G (blue) and H (gold) of one MPO homodimer. The two N-glycans pack tightly with each other at the dimer interface by symmetrically using the N-­acetylglucosamine (centre) β1,2-linked to the α1,6-arm of the trimannose core and the fucose α1,6-linked to the core GlcNAc1 (at the two extremities). Intermolecular and intermolecular hydrogen bonds, including water molecules, are shown as black dashed lines. The heme groups are present in both monomers and are shown as sea-green ball-and-stick models. Paroxetine is bound in one monomer per dimer and is not visible here as it is hidden behind the heme group of chain H. Green spheres represent chloride ions, pink spheres are calcium ions and red compositions are phosphate ions.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
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