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![[Figure 7]](cb5134fig7mag.jpg)
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Figure 7
(a) The Klenow fragment (KF; PDB entry 1d9f; chain A in brown) is superposed on PolI_G20c (PDB entry 7r0k; chain A in ice blue) displayed as tubes. The black line indicates the border between the small and large domain as described by Ollis et al. (1985  ) and the orange line indicates where the larger, palm domain starts at residue 299 in PolI_G20c and residue 228 in KF (corresponding to residue 551 in full-length DNA polymerase I from E. coli) according to InterPro. (b) Superposition of the best-matching structures based on a search using the DALI server. Chain A of DNA polymerase I from G. stearothermophilus (BF; PDB entry 1knc, gold), KF (PDB entry 2kzz, orange) and Taq polymerase (PDB entry 5ytf, violet) are superposed on chain A of PolI_G20c (ice blue) as ribbons. The structures match very well; however, α-helices 7 and 8 in PolI_G20c differ from all of the other compared enzymes and are part of a novel motif. The images were prepared with CCP4mg. |
![[Figure 7]](cb5134fig7.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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