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Figure 4
Cross-link between Aurora-A and MYCN. (a) 2FoFc electron density contoured at 1σ together with a model showing the ring-opened cross-link in cyan, Aurora-A in blue and MYCN in orange. (b) Mechanism of base-catalyzed ring hydrolysis. The hydroxyl group can perform a nucleophilic attack at either of the two carbonyl groups. The one depicted in bold is in better agreement with the observed electron density. The second possible attack of a hydroxyl group is shown in parentheses.

Journal logoSTRUCTURAL
ISSN: 2059-7983
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