Figure 1
Binding sites for AAVR on AAV2 and AAV5. Single copies of the PKD2 and PKD1 domains of AAVR (pink backbone) are shown as they are bound in structures of the AAV2 (top) and AAV5 (bottom) complexes, respectively (Meyer et al., 2019; Silveria et al., 2020). The viral surfaces (cream) are viewed with a similar perspective as in Fig. 5. When within 4.5 Å of receptor atoms, AAV amino acids are rainbow-colored by residue number from blue to red so that their location within a subunit can be registered by the corresponding color in Fig. 5. |