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Figure 3
cPLA2 hyperactivation and the arachidonic acid metabolism. During viral infection, cPLA2s are activated, releasing FFAs and lysophospholipids from the membrane to generate viral compartments and virions. Free LA inhibits cPLA2 and is metabolized into AA (chemical structures shown). AA is converted into diverse eicosanoids via three main pathways: cyclooxygenases, P450 and lipoxygenases. The resulting products, including prostaglandins (PG) and leukotrienes (LT), have important roles in the regulation of immune response (cytokine production), inflammation and beyond.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 79| Part 2| February 2023| Pages 111-121
https://doi.org/10.1107/S2059798323000049
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