Figure 4
Structural alignment of a penicillin-binding protein (PDB entry 2qmi), a β-lactamase (PDB entry 4gzb) and a polyglycine hydrolase, Fvan-cmp (PDB entry 7tpu). The global structural alignment of PDB entries 7tpu and 2qmi (a) and 4gzb (b) is shown. For each alignment, a focused view shows the active-site secondary structures and their global arrangement. Residues 276–297 and 365–447 were omitted for better visualization of the active site. The two conserved β-lactamase motifs within Fvan-cmp are labelled and shown in stick representation: Ser343, Lys346, Tyr447 and Asn449. The corresponding residues are represented in stick form for the penicillin-binding protein and β-lactamase. |