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Figure 1
Schematic illustration of the structures targeted by GH92 α-mannosidases. (a) The high-mannose N-glycan core (Hakki et al., 2015BB23). (b) α-Mannan found in the outer layer of the yeast cell wall; the α-1,6-linked backbone can reach a degree of polymerization of ∼200 (Orlean, 2012BB44). (c) An O-linked glycan (Goto, 2007BB22). The proteins produced in S. cerevisiae are often decorated with structures (a, c) that contribute to protein N- and O-glycosylation, respectively. The scheme was inspired by Hakki et al. (2015BB23). The green circles and blue squares are mannose and N-acetylglucosamine units, respectively, depicted according to the SNFG guidelines (Varki et al., 2015BB57; Neelamegham et al., 2019BB42)

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ISSN: 2059-7983
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