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Figure 6
Superposition and alignment of I. ricinus native serpin conformations. (a) Superposition of the Iripin-4 (PDB entry 7zbf), Iripin-1 (PDB entry 7qtz; Chlastáková et al., 2023BB3) and Iripin-8 (PDB entry 7pmu) crystal structures displayed as cartoons. The structure models are differentiated as follows: Iripin-4 is in blue, Iripin-1 is in red and Iripin-8 is in green. The structure of Iripin-1 was modified because of the absence of residues in its RCL, which are coloured salmon for emphasis. (b) A closer view of the RCL residues displayed as sticks; the colours are as described previously. (c) Structure-based sequence alignment of I. ricinus native serpins. The secondary-structure elements are depicted as arrows for β-strands and spirals for α-helices. The RCL is highlighted in a black box and the P1 and P1′ residues are marked according to the nomenclature of Schechter & Berger (1967BB44).

Journal logoSTRUCTURAL
ISSN: 2059-7983
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