Figure 7
Superposition and alignment of I. ricinus cleaved serpin conformations. (a) Superposition of the Iripin-4 (PDB entry 7zas), Iripin-2 (PDB entry 3nda), Iripin-3 (PDB entry 7ahp) and Iripin-5 (PDB entry 7b2t) crystal structures displayed as cartoons. The structure models are differentiated as follows: Iripin-4 is in blue, Iripin-2 is in grey, Iripin-3 is in magenta and Iripin-5 is in cyan. The RCL of all serpins is coloured salmon. (b) Structure-based sequence alignment of I. ricinus cleaved serpins. The secondary-structure elements are marked with arrows for β-strands and spirals for α-helices. The inserted RCL is highlighted in the black box and the P1 and P1′ residues are marked according to the nomenclature of Schechter & Berger (1967). |