Figure 3
The RSL–sclx8 interfaces in crystal form IV showing the unbiased electron-density maps (2Fo − Fc, calculated at 1.18 Å resolution prior to adding calixarenes to the model and contoured at 1σ). Two C2-symmetric interfaces are mediated by (a) one sclx8 molecule in the pleated loop and (b) two sclx8 molecules in a double-cone conformation. The sclx8 molecules are either wholly (a) or partly (b) located on a special position. Interface side chains are shown as sticks. For clarity, water molecules are omitted. |