Scipion Flexibility Hub: an integrative framework for advanced analysis of conformational heterogeneity in cryoEM

Herreros, D.; Krieger, J.M.; Fonseca, Y.; Conesa, P.; Harastani, M.; Vuillemot, R.; Hamitouche, I.; Serrano Gutiérrez, R.; Gragera, M.; Melero, R.; Jonic, S.; Carazo, J.M.; Sorzano, C.O.S.

doi:10.1107/S2059798323004497

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 3
Description of the focused heterogeneity workflow applied to the EMPIAR-10028 data set. The analysis reveals a new conformational landscape describing in a more informative manner the conformational changes affecting the L1 stalk region, which would remain hidden in the original landscape due to the size difference between the region of interest and the whole ribosome. In this way, it is possible to more easily inspect the localized conformational changes affecting the selected region in order to increase the knowledge of localized molecular motions.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 79| Part 7| July 2023| Pages 569-584

https://doi.org/10.1107/S2059798323004497

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