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![[Figure 1]](ji5031fig1mag.jpg)
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Figure 1
Overall structure of CauDHFR. (a) CauDHFR apoenzyme structure (cyan), with the subdomains highlighted in red and blue (α-helices shown in red and β-sheets shown in yellow; PDB entry 7zzx). (b) CauDHFR holoenzyme structure (blue; α-helices shown in red and β-sheets shown in yellow; PDB entry 8a0n). (c) Crystal structure of CauDHFR in complex with NADPH and PYR (green; PYR is in blue; α-helices are shown in red and β-sheets in yellow; PDB entry 8a0z). (d) Crystal structure of CauDHFR in complex with NAPDH and CYG (salmon; CYG is in blue; α-helices are shown in red and β-sheets in yellow; PDB entry 8crh). (e) Superposition of PDB entries 7zzx (cyan), 8a0n (blue) and 8a0z (green). (f) Electrostatic surface of PDB entry 8a0z. |
![[Figure 1]](ji5031fig1.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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