Figure 3
NADPH binding site and comparison to closely related enzymes. (a) Superimposed image of the NADPH binding site of the ternary complex of CauDHFR with NADPH and PYR (white; residues of interest are labelled in green; PDB entry 8a0z) and the CauDHFR apoenzyme (cyan, PDB entry 7zzx). (b) Superposition of the NADPH binding sites of the ternary complex of CauDHFR with residues of interest displayed (green; PDB entry 8a0z), CalDHFR (pink; PDB entry 3qlw) and CglDHFR (orange; PDB entry 3qlz). |