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![[Figure 4]](ji5031fig4mag.jpg)
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Figure 4
Substrate-binding site in CauDHFR. (a) Superposition of CauDHFR–NADPH–PYR (white; residues of interest are in green; PDB entry 8a0z), CalDHFR (pink; PDB entry 3qlw) complexed with the antifolate N22 and CglDHFR (orange; PDB entry 3qlz) complexed with the antifolate QLZ. (b) Electrostatic surface of the CauDHFR–NADPH–PYR ternary complex (NADPH in green and PYR in blue; PDB entry 8a0z). (c) Electrostatic surface of the CauDHFR–NADPH–CYG ternary complex (NADPH in pink and CYG in yellow; PDB entry 8crh). |
![[Figure 4]](ji5031fig4.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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