Figure 5
(a) Ternary complex of CauDHFR with NADPH and PYR, with the residues interacting with the amine groups of PYR highlighted (white; residues of interest in green and PYR in blue; PDB entry 8a0z). (b) Superposition of CauDHFR–NADPH–PYR (white; residues of interest in green; PDB entry 8a0z), the CauDHFR–NADPH–CYG ternary complex (pink; PDB entry 8crh), the CauDHFR apoenzyme (cyan; PDB entry 7zzx) and the CauDHFR holoenzyme (blue; PDB entry 8a0n). |