Figure 6
Active-site superposition of CauDHFR and HsDHFR. (a) Superposition of C. auris DHFR (green; PDB entry 8a0z) and H. sapiens DHFR (salmon; PDB entry 4m6j). (b) Superposition of CauDHFR–NADPH–PYR (white; residues of interest in green; PDB entry 8a0z) and HsDHFR (salmon; PDB entry 4m6j). |