Structural basis of the amidase ClbL central to the biosynthesis of the genotoxin colibactin

Tripathi, P.; Mousa, J.J.; Guntaka, N.S.; Bruner, S.D.

doi:10.1107/S2059798323005703

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 1
ClbL-mediated transacylation of colibactin NRPS–PKS intermediates. Phosphopantetheinyl thioesters of the ACP domains of ClbO and ClbI are substrates for ClbL transamidation. The bond-forming step (blue square) and product amide (blue circle) are highlighted.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 79| Part 9| September 2023| Pages 830-836

https://doi.org/10.1107/S2059798323005703

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