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Figure 3
Substrate–ClbL active-site interactions. (a) Schematic of the overall ClbL reaction and substrate interactions. The overall pathway is shown along with the interactions of a modeled PMSF adduct (boxed). R1 and R2 represent the extended end chains of precolibactin (Fig. 1[link]). (b) Composite omit electron-density map, contoured at 1.0 Å, of the modeled phenylmethylsulfonyl–Ser179 adduct. Hydrogen-bonding distances are 2.7 Å (Ser155/sulfonyl) and 3.2 Å (Ser155 cis-amide/sulfonyl). (c) ClbL surface representation of a modeled bound substrate (Supplementary Fig. S5, yellow).

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 79| Part 9| September 2023| Pages 830-836
https://doi.org/10.1107/S2059798323005703
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