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Figure 5
Close-up view of the NADPH-binding pocket of Msm-TrxR with bound fragments (light blue) in comparison to bound NADPH (green). (a) In comparison to the bound NADPH (green, overlay from PDB entry 8ccj), the bound fragments are located deeper in the binding site. Arg178, Arg179 and Arg183 show rearrangement around the fragments and close the binding site in comparison to the NADPH-bound conformation. (b) Nine fragments are bound to the NADPH-binding pockets and show hydrogen bonds to the backbone of Leu121, Ile206 and His177. Hydrogen bonds are shown as black dashed lines.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 79| Part 9| September 2023| Pages 857-865
https://doi.org/10.1107/S2059798323005223
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