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Figure 1
Results of unit-cell-based HCA of in silico mixed data sets containing apo and benzamidine-bound trypsin. (a) Resultant dendrogram. The definitions of `node', `branch' and `cluster' used in this study are illustrated in the dendrogram. Cluster numbers and data labels are depicted on the resultant dendrogram from unit-cell-based HCA. The blue numbers indicate the cluster numbers at each node. Chunks for apo trypsin are shaded green and those for benzamidine-bound trypsin are colored orange. (b)–(e) Electron-density maps around the inhibitor-binding site of trypsin in different clusters. The contour level of the 2FoFc map (gray mesh) is 1.0σ and that of the FoFc map (green mesh) is 3.0σ. The maps were generated by Coot in the NABE system.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
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