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![[Figure 1]](wa5143fig1mag.jpg)
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Figure 1
Results of unit-cell-based HCA of in silico mixed data sets containing apo and benzamidine-bound trypsin. (a) Resultant dendrogram. The definitions of `node', `branch' and `cluster' used in this study are illustrated in the dendrogram. Cluster numbers and data labels are depicted on the resultant dendrogram from unit-cell-based HCA. The blue numbers indicate the cluster numbers at each node. Chunks for apo trypsin are shaded green and those for benzamidine-bound trypsin are colored orange. (b)–(e) Electron-density maps around the inhibitor-binding site of trypsin in different clusters. The contour level of the 2Fo − Fc map (gray mesh) is 1.0σ and that of the Fo − Fc map (green mesh) is 3.0σ. The maps were generated by Coot in the NABE system. |
![[Figure 1]](wa5143fig1.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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