A user-friendly plug-and-play cyclic olefin copolymer-based microfluidic chip for room-temperature, fixed-target serial crystallography

Liu, Z.; Gu, K.K.; Shelby, M.L.; Gilbile, D.; Lyubimov, A.Y.; Russi, S.; Cohen, A.E.; Narayanasamy, S.R.; Botha, S.; Kupitz, C.; Sierra, R.G.; Poitevin, F.; Gilardi, A.; Lisova, S.; Coleman, M.A.; Frank, M.; Kuhl, T.L.

doi:10.1107/S2059798323007027

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 1
(a) A schematic of the improved chip construction layers. Note that `top' frames (layer 2) have inlet holes while `bottom' frames do not. (b) Image of the assembled chip with sample X-ray imaging areas filled with colored solution. The dashed red line demarks the active X-ray imaging area. The sample is loaded by manual pipetting into one of the inlet/outlet holes. Each sample-imaging window is independent.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 79| Part 10| October 2023| Pages 944-952

https://doi.org/10.1107/S2059798323007027

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