A user-friendly plug-and-play cyclic olefin copolymer-based microfluidic chip for room-temperature, fixed-target serial crystallography

Liu, Z.; Gu, K.K.; Shelby, M.L.; Gilbile, D.; Lyubimov, A.Y.; Russi, S.; Cohen, A.E.; Narayanasamy, S.R.; Botha, S.; Kupitz, C.; Sierra, R.G.; Poitevin, F.; Gilardi, A.; Lisova, S.; Coleman, M.A.; Frank, M.; Kuhl, T.L.

doi:10.1107/S2059798323007027

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 5
(a) Representative images of lysozyme crystals and the variation in crystal density in the two chips before XFEL measurements (the scale bar applies to both parts of the figure). (b) Lysozyme crystals five days after XFEL measurements at 50 µm shot spacing, 11% transmission and 0.9–1.0 mJ pulse energy. Small vapor bubbles of a few micrometres in size were observed in some areas of the microfluidic channel where the beam was rastered, as highlighted by the dashed circles and the inset.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 79| Part 10| October 2023| Pages 944-952

https://doi.org/10.1107/S2059798323007027

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