Figure 1
Crystal structure of human DHX9 bound to ADP. (a) Domain structure of human DHX9. Domains included in the crystallization construct (amino acids 150–1150) are outlined with solid lines. dsRBD1, dsRNA-binding domain 1; L1, linker 1; dsRBD2, dsRNA-binding domain 2; L2, linker 2; MTAD, minimal transactivation domain; RecA1, RecA-like domain 1; RecA2, RecA-like domain 2; HA2, helicase-associated 2 domain; OB, OB-fold domain; L3, linker 3; RGG, Arg-Gly-Gly-rich domain. (b) Structure of human DHX9 (ribbon) bound to ADP (green sticks). The color scheme for individual domains in Fig. 1(a) is applied to the ribbon representation in Fig. 1(b). |