Figure 7
Structural changes at the exit site of the RNA channel. The color scheme for DHX9 is identical to that in Fig. 1; MLE is shown in gray and RNA is in dark blue. (a) Superposition of DHX9 and MLE shows structural changes of secondary structures that impact the RNA channel. (b) A composite cartoon and surface representation of DHX9 shows structural changes that result in complete closure of the RNA exit site. (c) Side-chain movements in RecA1 and domain movements of the secondary structure of the HA domain impact the RNA exit site. Residues are shown in stick representation. |