The bad and the good of trends in model building and refinement for sparse-data regions: pernicious forms of overfitting versus good new tools and predictions

Richardson, J.S.; Williams, C.J.; Chen, V.B.; Prisant, M.G.; Richardson, D.C.

doi:10.1107/S2059798323008847

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 4
Barbed-wire regions versus near-folded regions in low-pLDDT AlphaFold predictions from the EBI AFDB. (a) Overview of the AF model for Saccharomyces cerevisiae UniProt P53076. (b) Close-up of a classic barbed-wire segment in the AF model for human UniProt Q1HG43, with MolProbity validation markup. (c) A near-folded model for Methanocaldococcus jannaschii UniProt Q57775 (pLDDT < 70 in yellow and pLDDT < 50 in orange).

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 79| Part 12| December 2023| Pages 1071-1078

https://doi.org/10.1107/S2059798323008847

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