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Figure 2
Comparison of the different assembly modes. (a) Four consecutive N–VHH complexes within the crystal are shown as coloured surfaces. The N protein of the complex is alternatively coloured blue and orange, while the VHH proteins are shown in yellow. (b) The complexes are aligned antiparallel to each other as marked by the black arrows. On the left, two N–VHH complexes are presented as described previously using the colour code described above. On the right, a molecular model of the nucleoprotein of Toscana virus (PDB entry 5fva) is presented. The black arrows show the orientation of the N proteins in both cases. (c) Superimposition of apo N (green) with N from the N–VHH structure (orange). Structures are shown in ribbon representation and show that when the cores are superimposed the N-terminal extension of N–VHH is flipped and distorted.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
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