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![[Figure 1]](qi5004fig1mag.jpg)
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Figure 1
Different applications of pressurized gases in macromolecular crystallography. (1) Mapping of tunnels connecting the external solvent to the buried active site of an enzyme, (2) of transport channels passing through macromolecules, (3) of excavations at surfaces of macromolecules that may have allosteric effects (3↔5) and (4) of internal cavities. (5) Studies of possible reactions of non-inert gases (oxygen, carbon dioxide and methane…) at the active sites of specific enzymes. (6) Exploration of protein conformational fluctuations induced by pressure. (7) Cryo-cooling of crystals without any addition of cryo-protectant at 2000 bar. |
![[Figure 1]](qi5004fig1.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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