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Figure 4
Binding of imide fragments and the blocked binding cleft in the closed crystal form. (a) Cpd-20 and (b) cpd-21 bind congruently, with their respective N-linked succinimide portions in the S4 pocket. Potential exit vectors towards the catalytic centre are indicated by arrows. (c) These fragments would clash with a crystal mate (orange surface; PDB entry 5rgr) in the closed crystal form; structures are aligned with respect to the protein monomer binding cpd-20. (d) The more open crystal form used in this study allows unobstructed access to the complete binding cleft (the closest crystal mate is shown as a green surface).

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
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