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![[Figure 6]](ih5004fig6mag.jpg)
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Figure 6
The human MCIA complex. (a) Cryo-EM structure of the human ACAD9–ECSITCTER complex, formed in vitro from subunits expressed in E. coli, with a schematic of the sequences of ACAD9 and ECSIT that were modelled in the EM map. Reprinted from McGregor et al. (2023  ). (b) AlphaFold-Multimer prediction of human ACAD9 (two copies), ECSIT (two copies), NDUFAF1 and ND2 in two different orientations. The left panel shows only ECSIT residues 320–334 that were modelled in the EM structure; the right panel shows the high-confidence prediction of one copy. Black arrows indicate amphipathic membrane anchors. The insets show the amphipathic helices of ACAD9 (460–475, yellow) and NDUFAF1 (81–106, cyan). (c) The Y. lipolytica early PP module intermediate in the same orientations aligned on ND2. |
![[Figure 6]](ih5004fig6.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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