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Figure 7
The role of NDUFAF2 in complex I assembly in Y. lipolytica. Left: the assembly intermediate from the ndufs6Δ strain (PDB entry 6rfq). The assembly factor NDUFAF2 (violet) is bound to the Q module (wheat) instead of NDUF12; NDUFS4 (green) is already in place. Right: in mature complex I (PDB entry 7o71), NDUFA12 (dark magenta) has replaced the assembly factor NDUFAF2, and NDUFS6 (medium purple) covers its C-terminus. Below: structure comparison and sequence alignment of NDUFAF2 and NDUFA12. β-Strands are shown in cyan, the N-terminal helices of NDUFA12 in lime and the other helices in yellow. The disordered N-terminus and 100-residue insert of NDUFAF2 are indicated in grey.

Journal logoSTRUCTURAL
BIOLOGY
ISSN: 2059-7983
Volume 80| Part 3| March 2024| Pages 159-173
https://doi.org/10.1107/S205979832400086X
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