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![[Figure 1]](jb5061fig1mag.jpg)
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Figure 1
Upper mevalonate pathways in eukaryotes/eubacteria and archaea, showing the enzymes in bold. Blue arrows show enzymes that are found only in archaea, green arrows show reactions that are only present in eukaryotes/prokaryotes and red arrows show a non-exhaustive list of metabolites known to inhibit eukaryotic/prokaryotic enzymes. AAT, acetyl-CoA acetyltransferase; HMGS, hydroxymethylglutaryl-CoA synthase; HMGR, hydroxymethylglutaryl-CoA reductase; MK, mevalonate kinase; M3K, mevalonate-3-kinase; M3P5K, mevalonate-3-phosphate-5-kinase; PMK, phosphomevalonate kinase; MPPD, mevalonate-3,5-pyrophosphate decarboxylase; MP5D, mevalonate-5-phosphate decarboxylase; MPD, mevalonate pyrophosphate decarboxylase; IPK, isopentenyl kinase; IDI, isopentenyl diphosphate isomerase; CoA, coenzyme A; HMG, hydroxymethylglutaryl; NADP, nicotinamide adenine dinucleotide phosphate; FPP, farnesyl pyrophosphate; GPP, geranyl pyrophosphate; GGPP, geranyl pyrophosphate synthase. |
![[Figure 1]](jb5061fig1.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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