Figure 7
Surface representation and surface of (a) MKvar, (b) MKrat, (c) MKmaz and (d) MKbur with mevalonate and ATP shown as sticks. The yellow portion is the lid, blue represents motif II and dark red represents a variable nucleotide-binding loop; the dark green section represents the end of helix α4/α1 (in MKvar/MKbur) or the equivalent in MKrat and MKmaz. The measurement represents the distance in Å between the N-terminus of helix α4/α1 (in MKvar/MKbur) and the loop lid. The localization of ATP is estimated by alignment with MKrat crystallized with ATP in the active site. |