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![[Figure 4]](rr5245fig4mag.jpg)
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Figure 4
Electron-density maps of structures of EP in complex with TL00150 and AC40075 with the cryoloop–Paratone-N oil setup under cryo and RT conditions. The EP structure is shown in cartoon representation, and fragments and surrounding residues are shown in stick representation. The cryo and RT structures are colored gray and magenta, respectively. The 2Fo − Fc electron-density maps contoured at the 1.0σ level with blue-colored mesh around the fragment-binding pocket and flap domain (residues Ser76–Ser86) of the EP structures are shown. The Fo − Fc electron-density maps generated using the model without the fragment are also shown contoured at the 2.5σ level and colored green. |
![[Figure 4]](rr5245fig4.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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