Figure 3
Fragment-binding events at the ECH active site. View into the ECH acyl-tail binding tunnel. The C-terminal helix of the crotonase fold (helix H10) covers the ECH active site. Also included are CoA as bound to the ECH active site [magenta, labeled CoA(ECH)], as well as the CoA bound in the CoA-C(ECH/HAD) site [magenta, labeled CoA(CoA-C)]. The bound fragments cover the active-site pocket (E1, E2 and E3) and extend to the exit of the ECH acyl-tail binding tunnel. |