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![[Figure 5]](ud5051fig5mag.jpg)
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Figure 5
Properties of the protein surface of the possible substrate-channeling path between the three active sites of MtTFE. The image shows the color-coded molecular surface of the CoA-C(ECH/HAD) region, near the interface of chain A (α subunit) and chain D (β subunit) of the CoA-C structure (PDB entry 7o4t), color-coded such that the blue and red colors identify surface regions with positive and negative electrostatic potential, respectively. Neutral regions have a white color. The active sites are identified as CoA(ECH) (with an arrow), NAD+(HAD) (of the α subunit) and CoA(KAT) (of the β subunit). The CoA molecule bound at the CoA-C(ECH/HAD) site (I2) at the center of the surface between the three active sites is also included. I1, H1 and I3 identify the binding regions extending from I2 towards the ECH, HAD and KAT active sites, respectively. Also shown is CoA bound in the CoA-B(ECH2) site. A stereo figure is shown in Supplementary Fig. S3 and a video (Supplementary Movie S1) is also provided. The fragments included in the image are indicated in the inset, which schematically visualizes the locations of the I1, I2 and I3 sites with respect to the three catalytic sites in the same view as used for the molecular-surface image. |
![[Figure 5]](ud5051fig5.jpg)
 | STRUCTURAL BIOLOGY |
ISSN: 2059-7983
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