Microcrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assembly

Li, Y.; Pacoste, L.C.; Gu, W.; Thygesen, S.J.; Stacey, K.J.; Ve, T.; Kobe, B.; Xu, H.; Nanson, J.D.

doi:10.1107/S2059798324008210

Acta Crystallographica Section D
Acta Crystallographica
Section D STRUCTURAL BIOLOGY

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Figure 5
Time-lapse imaging of MyD88^TIR microcrystal formation nucleated by TLR2^TIR. Seeds were rinsed to remove free TLR2^TIR and then incubated with MyD88^TIR. DIC images were taken at different time points: (a) 10 min, (b) 30 min and (c) 60 min. Unidirectional elongation of microcrystals was observed. Selected microcrystals or clusters of microcrystals are indicated by a black star; black arrows indicate the direction of crystal elongation.

STRUCTURAL
BIOLOGY

ISSN: 2059-7983

Volume 80| Part 9| September 2024| Pages 699-712

https://doi.org/10.1107/S2059798324008210

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